Pioneering Health Solutions for Earth and Beyond

Nicole Stott, NASA Astronaut (Ret.):

As an astronaut, I understand the toll that extreme environments take on the body. OxSHIELD presents a promising innovation in wearable tech aimed at mitigating oxidative stress—something I believe could have a meaningful impact both in space and here on Earth.”
— Nicole Stott, NASA Astronaut (Ret.)
Nicole is also the author of Back to Earth: What Life in Space Taught Me About Our Home Planet—and Our Mission to Protect It

Dr. Dorit Donoviel, Director, NASA TRISH:

The Translational Research Institute for Space Health (TRISH) has expressed interest in OxSHIELD for potential future missions—highlighting its alignment with NASA’s focus on astronaut health and next-generation space medicine.
— Dr. Dorit Donoviel, Director, NASA TRISH
Dr. Donoviel also serves as Associate Professor in Space Medicine at Baylor College of Medicine and leads national efforts in cutting-edge space health innovation

🔬 Research & Evidence

Scientific Foundations of Electron Supplementation and Grounding

OxShield leverages cutting-edge science to combat oxidative stress, a root cause of bone loss, chronic diseases, and aging. By delivering electrons to neutralize harmful free radicals, OxShield promotes health in space, clinical settings, and daily life. These studies highlight its potential across diverse applications.

Study 1:

Title: Capacity of Omega-3 Fatty Acids or Eicosapentaenoic Acid to Counteract Bone Loss Associated with Spaceflight
Authors: Zwart, S. R., et al. (2010)
Published in: Journal of Bone and Mineral Research, 25(5), 1049–1057
Summary: This study investigated the potential of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), to mitigate bone loss associated with spaceflight. The researchers found that higher dietary intake of omega-3 fatty acids was associated with reduced bone resorption markers in astronauts after short-duration spaceflight. Additionally, cell culture studies demonstrated that EPA could inhibit the activation of NF-κB, a transcription factor linked to bone resorption. These findings suggest that omega-3 fatty acids may serve as a nutritional countermeasure to bone loss in microgravity environments.

OxShield’s targeted electron delivery system aligns with these findings by aiming to reduce oxidative stress, a key factor in bone resorption during spaceflight. By supplying electrons directly to the body, OxShield may offer a portable and innovative approach to preserving bone health in microgravity conditions.

Access the full article here: PubMed – PMID: 19874203

---

Study 2:

Title: Antioxidant Strategy to Prevent Simulated Microgravity-Induced Oxidative Stress in Osteoblast Cells
Authors: Morabito, C., et al. (2020)
Summary: This study investigated the impact of simulated microgravity on osteoblast cells, specifically focusing on oxidative stress and its effects on cell morphology, proliferation, and metabolism. Using murine MC3T3-E1 osteoblast cells exposed to simulated microgravity, researchers observed increased levels of reactive oxygen species (ROS), disrupted cytoskeletal architecture, and a slowdown in the proliferative rate. Notably, the application of the antioxidant Trolox effectively inhibited these adverse effects, preserving cell structure and function. The findings suggest that antioxidant strategies could serve as effective countermeasures against microgravity-induced oxidative stress in bone-forming cells, highlighting the potential of interventions like OxShield in protecting astronaut bone health during extended space missions.
This research underscores the significance of oxidative stress in bone degradation under microgravity and supports the exploration of antioxidant solutions to mitigate such effects.

Access the full study: PubMed

---

Study 3:

Title: The Effects of Grounding (Earthing) on Inflammation, the Immune Response, Wound Healing, and Prevention and Treatment of Chronic Inflammatory and Autoimmune Diseases
Authors: James L. Oschman, Gaétan Chevalier, and Richard Brown (2015)
Summary: This comprehensive review explores how grounding—direct physical contact with the Earth’s surface—affects human physiology. The authors present evidence that grounding can reduce inflammation, improve immune responses, accelerate wound healing, and serve as a preventive and therapeutic strategy for chronic inflammatory and autoimmune diseases. The proposed mechanism involves the transfer of electrons from the Earth to the body, which neutralizes reactive oxygen species (ROS) and reduces oxidative stress. The study highlights measurable differences in white blood cell counts, cytokine levels, and other inflammatory markers in grounded individuals, suggesting that grounding can modulate the inflammatory response and enhance overall health.

This research supports the concept that electron transfer from the Earth can have significant health benefits, aligning with the principles behind OxShield’s targeted electron delivery system. By supplying electrons directly to the body, OxShield may mimic the beneficial effects of natural grounding, offering a portable solution to combat oxidative stress and support overall health, including potential benefits for bone preservation in space environments.

Access the study here: Scribd

---

Study 4:

Title: Microcurrent Therapy as a Therapeutic Modality for Musculoskeletal Pain: A Systematic Review Accelerating the Translation From Clinical Trials to Patient Care
Authors: Hirotaka Iijima, PhD, PT; Masaki Takahashi, PhD
Published: September 2021 in Archives of Rehabilitation Research and Clinical Translation
Summary: This systematic review evaluated the efficacy and safety of microcurrent therapy (MCT) in treating musculoskeletal pain. Analyzing data from four randomized controlled trials and five non-randomized studies, the authors found that MCT significantly improved shoulder and knee pain compared to sham treatments, with no severe adverse events reported. Notably, the study highlighted a substantial placebo response, accounting for 57% of the overall treatment effect in subacute to chronic knee pain, suggesting that both the therapy and patient expectations contribute to pain relief. The findings support MCT as a promising nonpharmacologic treatment option for musculoskeletal pain, warranting further high-quality research to enhance study reproducibility and clinical application.

These insights align with the principles behind OxShield’s targeted electron delivery system. By supplying low-level electrical currents to the body, OxShield may mimic the beneficial effects of MCT, offering a portable solution to manage chronic conditions linked to oxidative stress, such as arthritis or fibromyalgia.

Access the study here: PMC

---

Study 5:

Title: The Redox Stress Hypothesis of Aging
Authors: Sohal, R. S., & Orr, W. C. (2012)
Published in: Free Radical Biology and Medicine
Summary: This comprehensive review presents the redox stress hypothesis, which posits that aging results from a progressive shift in the cellular redox environment towards a more oxidizing state. This shift leads to cumulative oxidative damage to macromolecules, contributing to the functional decline associated with aging and the development of age-related diseases. The authors discuss the role of reactive oxygen species (ROS) not only as damaging agents but also as signaling molecules that can influence gene expression and cellular function. They emphasize that maintaining redox homeostasis is crucial for healthy aging and suggest that interventions targeting redox balance could mitigate age-associated physiological deterioration.

These insights align with the principles behind OxShield’s targeted electron delivery system. By supplying electrons directly to the body, OxShield may help restore redox balance, neutralize excess ROS, and support overall health and longevity.

Access the full article here: PubMed